一类新型冠醚稀土配合物的合成、表征及与DNA作用研究Synthesis,Characterization and DNA-Binding of Rare Earth Complexes with A Novel Crown Ether
李寒玉;杨天林;丁玲;王文华;
摘要(Abstract):
合成了四种双(N,N′-乙基,苯基)-2,3-萘-二(氧杂乙酰胺)(L=C30H30N2O4)稀土配合物。通过元素分析、红外光谱、差热-热重及摩尔电导值的分析,确定配合物的组成为[RE(pic)3L],RE=Eu(Ⅲ),Tb(Ⅲ),Ce(Ⅲ),Y(Ⅲ)。电化学实验表明:配体无电化学活性,配合物则呈现出一准可逆的氧化还原过程,在10~1000 mV.s-1扫速范围内配合物的氧化还原峰电流与扫描速度的平方根(ν1/2)呈良好的线性关系,表明其在玻碳电极(GCE)上的伏安行为受扩散控制。另外,通过循环伏安法、光谱法及粘度法研究了配合物与DNA的作用方式,结果表明:配合物均以插入方式与DNA作用,并且作用大小次序是Ce(pic)3L>Tb(pic)3L>Y(pic)3L>Eu(pic)3L。在pH=3.0适宜酸度条件下,建立了以Ce(pic)3L为探针定量测定DNA的分析方法。
关键词(KeyWords): 开链冠醚;稀土配合物;电化学性质;插入作用
基金项目(Foundation): 教育部科学技术研究重点基金资助项目(208159);; 甘肃省有色金属化学与资源利用重点实验室开放课题基金资助项目(2010)
作者(Authors): 李寒玉;杨天林;丁玲;王文华;
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